Ketamine Therapy

About Ketamine Infusion Therapy

  • Alternative treatment option for patients with treatment-resistant depression

  • Can result in rapid relief of depression and/or suicidal thoughts within hours or days

  • Performed on an outpatient basis in our Houston office

  • Involves 6 administrations of ketamine via an IV over a 2-3-week period

  • Effects of ketamine therapy do wear off

  • Not covered by insurance and not FDA-approved for the treatment of depression

Ketamine therapy consists of a series of small doses of ketamine administered by a medical professional over a series of days to relieve the symptoms of severe depression, PTSD, OCD, and more.  Relief for those who respond to ketamine therapy often happens within minutes of receiving ketamine, but may take up to 24 hours or require a second dose. Ketamine treatments happen at a clinic or doctor’s office, and patients are monitored during and after the administration of the drug.

Dr. St. John began providing outpatient ketamine infusion services in early 2017 with the aim of further improving the lives of patients who suffer from treatment-resistant depression and who have found no relief of their symptoms with FDA-approved treatments like medications, psychotherapy, TMS, or even ECT.

Ketamine Infusion FAQs

Please visit our Frequently Asked Questions page to get your questions answered regarding Ketamine Infusion.

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About Spravato Esketamine

Esketamine, or Spravato, is another treatment derived from ketamine that makes powerful antidepressant relief available to be delivered intra-nasally, similar to a common nasal decongestant.

What is esketamine therapy?

Esketamine, or Spravato, is the first nasal spray medication that is a treatment for depression. Combined with an antidepressant, Spravato is FDA-approved to treat depression and has been clinically shown to improve symptoms of depression over just 4 weeks.

What is an esketamine treatment like?

Unlike antidepressants, which need to be taken every day, Spravato is only administered a couple of times each week: Two treatments per week for the first month, then one treatment per week for the second month, and one treatment every two weeks for subsequent months.


Esketamine therapy patients generally report some sedation and disassociation effects during or shortly after the administration of the drug. Other side effects may include nausea, dizziness, vertigo, or headache.

Is esketamine therapy safe?

Spravato has been FDA-approved since 2019 and evaluated in both short- and long-term trials for safety and efficacy. Because Spravato is administered in our office, patients will be monitored closely for any adverse side effects. 


Before starting esketamine therapy, we will discuss all potential side effects and interactions, and make sure Spravato is right for you.  

Dr Martha St John Spravato Ketamine in Houston